intermittent therapy meaning in English

间歇疗法,间歇给药法

Studies of the crystal structure of endostatin have shown a compact globular fold , with one face particularly rich in arginine residues acting as a heparin - binding epitope , this site was recently shown to be involved in the inhibition of induced angiogenesis . experimental studies show that recombinant endostatin specifically inhibits the proliferation of endothelial cells in a dosedependent fashion . recombinant endostatin from bacteria is largely insoluble , but still efficient in arresting tu mor growth after injection into mice . intermittent therapy with recombinant bacterially produced endostatin reduces several experimental tumors , including lewis lung carcinoma , to a dormant state . no sign of drug induced resistance has been reported and , in the original study , the treatment dormancy appeared to persist even when therapy was discontinued . sowe regard endostatin as a promising anti - tumor drug
许多研究表明重组内皮抑素特异性抑制内皮细胞增殖，而且这种抑制作用呈剂量依赖性。细菌表达产物内皮抑素大部分以不溶形式存在，将这种混悬液注射治疗老鼠仍可以抑制肿瘤生长。于小鼠皮下重复注射内皮抑素重组蛋白，几乎完全抑制鼠lewis肺癌等多种肿瘤生长，并无耐药性产生，即使中断治疗肿瘤也不再复发。